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A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder

Cited 70 time in Web of Science Cited 73 time in Scopus
Authors
Jang, Joon Hwan; Kwon, Jun Soo; Jang, Dong Pyo; Moon, Won-Jin; Lee, Jong-Min; Ha, Tae Hyun; Chung, Eun Chul; Kim, In Young; Kim, Sun I
Issue Date
2006-07-04
Publisher
American Psychiatric Publishing
Citation
Am J Psychiatry. 2006 Jul;163(7):1202-7.
Keywords
AdultAspartic Acid/*analogs & derivatives/metabolismBrain/drug effects/*metabolismBrain Chemistry/drug effectsCholine/metabolismCitalopram/*pharmacokinetics/*therapeutic useCreatine/metabolismFemaleFrontal Lobe/drug effects/metabolismGyrus Cinguli/drug effects/metabolismHumansLongitudinal Studies*Magnetic Resonance SpectroscopyMaleObsessive-Compulsive Disorder/diagnosis/*drug therapy/metabolismPersonality InventoryPrefrontal Cortex/drug effects/metabolismProtonsPsychiatric Status Rating ScalesSerotonin Uptake Inhibitors/*pharmacokinetics/*therapeutic use
Abstract
OBJECTIVE: Reductions in the level of N-acetylaspartate within subcortical structures of patients with obsessive-compulsive disorder (OCD) have been reported in several studies. However, there have been, as yet, no reports regarding N-acetylaspartate levels in the prefrontal cortex of adult drug-naive OCD patients. The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were included in this study. N-acetylaspartate levels (obtained from ratios of N-acetylaspartate with creatine, choline, and creatine plus choline) in the prefrontal cortex, parietal cortex, anterior cingulate, posterior cingulate, frontal white matter, and parietal white matter were measured by (1)H-MRSI. In OCD patients, measurements were taken before and after 12 weeks of citalopram treatment. Correlations between N-acetylaspartate concentrations in regions of interest and clinical measures were also assessed. RESULTS: Drug-naive OCD patients exhibited significantly lower N-acetylaspartate levels in the prefrontal cortex, frontal white matter, and anterior cingulate at baseline than did comparison subjects. Significant increases in N-acetylaspartate level were detected in the prefrontal cortex and frontal white matter in OCD patients after 12 weeks of citalopram treatment. CONCLUSIONS: These data suggest that reductions in neuronal viability occur in the frontal region of OCD patients and that these reductions may be partly reversible.
ISSN
0002-953X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816225

https://hdl.handle.net/10371/29582
DOI
https://doi.org/10.1176/appi.ajp.163.7.1202
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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