S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
- Jang, Joon Hwan; Kwon, Jun Soo; Jang, Dong Pyo; Moon, Won-Jin; Lee, Jong-Min; Ha, Tae Hyun; Chung, Eun Chul; Kim, In Young; Kim, Sun I
- Issue Date
- American Psychiatric Publishing
- Am J Psychiatry. 2006 Jul;163(7):1202-7.
- Adult; Aspartic Acid/*analogs & derivatives/metabolism; Brain/drug effects/*metabolism; Brain Chemistry/drug effects; Choline/metabolism; Citalopram/*pharmacokinetics/*therapeutic use; Creatine/metabolism; Female; Frontal Lobe/drug effects/metabolism; Gyrus Cinguli/drug effects/metabolism; Humans; Longitudinal Studies; *Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder/diagnosis/*drug therapy/metabolism; Personality Inventory; Prefrontal Cortex/drug effects/metabolism; Protons; Psychiatric Status Rating Scales; Serotonin Uptake Inhibitors/*pharmacokinetics/*therapeutic use
- OBJECTIVE: Reductions in the level of N-acetylaspartate within subcortical structures of patients with obsessive-compulsive disorder (OCD) have been reported in several studies. However, there have been, as yet, no reports regarding N-acetylaspartate levels in the prefrontal cortex of adult drug-naive OCD patients. The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were included in this study. N-acetylaspartate levels (obtained from ratios of N-acetylaspartate with creatine, choline, and creatine plus choline) in the prefrontal cortex, parietal cortex, anterior cingulate, posterior cingulate, frontal white matter, and parietal white matter were measured by (1)H-MRSI. In OCD patients, measurements were taken before and after 12 weeks of citalopram treatment. Correlations between N-acetylaspartate concentrations in regions of interest and clinical measures were also assessed. RESULTS: Drug-naive OCD patients exhibited significantly lower N-acetylaspartate levels in the prefrontal cortex, frontal white matter, and anterior cingulate at baseline than did comparison subjects. Significant increases in N-acetylaspartate level were detected in the prefrontal cortex and frontal white matter in OCD patients after 12 weeks of citalopram treatment. CONCLUSIONS: These data suggest that reductions in neuronal viability occur in the frontal region of OCD patients and that these reductions may be partly reversible.
- 0002-953X (Print)
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