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Long-term depression of mGluR1 signaling
Cited 31 time in
Web of Science
Cited 28 time in Scopus
- Authors
- Issue Date
- 2007-07-21
- Publisher
- Cell Press
- Citation
- Neuron. 2007 Jul 19;55(2):277-87.
- Keywords
- Animals ; Calcium Signaling/physiology ; Excitatory Postsynaptic Potentials/*physiology ; Long-Term Synaptic Depression/*physiology ; Nerve Fibers/metabolism ; Patch-Clamp Techniques ; Purkinje Cells/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/*metabolism ; Synaptic Transmission/*physiology
- Abstract
- Glutamate produces both fast excitation through activation of ionotropic receptors and slower actions through metabotropic receptors (mGluRs). To date, ionotropic but not metabotropic neurotransmission has been shown to undergo long-term synaptic potentiation and depression. Burst stimulation of parallel fibers releases glutamate, which activates perisynaptic mGluR1 in the dendritic spines of cerebellar Purkinje cells. Here, we show that the mGluR1-dependent slow EPSC and its coincident Ca transient were selectively and persistently depressed by repeated climbing fiber-evoked depolarization of Purkinje cells in brain slices. LTD(mGluR1) was also observed when slow synaptic current was evoked by exogenous application of a group I mGluR agonist, implying a postsynaptic expression mechanism. Ca imaging further revealed that LTD(mGluR1) was expressed as coincident attenuation of both limbs of mGluR1 signaling: the slow EPSC and PLC/IP3-mediated dendritic Ca mobilization. Thus, different patterns of neural activity can evoke LTD of either fast ionotropic or slow mGluR1-mediated synaptic signaling.
- ISSN
- 0896-6273 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17640528
https://hdl.handle.net/10371/29742
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