Publications
Detailed Information
Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Ko, Seong Gyu | - |
dc.contributor.author | Kim, Hwang-Phill | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.contributor.author | Bae, Hyun-Su | - |
dc.contributor.author | Kim, Sung Hoon | - |
dc.contributor.author | Park, Chong-Hyeong | - |
dc.date.accessioned | 2009-05-15T04:27:16Z | - |
dc.date.available | 2009-05-15T04:27:16Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Cancer Letters 220 (2005) 11–19 | en |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://www.elsevier.com/locate/canlet | - |
dc.identifier.uri | https://hdl.handle.net/10371/3242 | - |
dc.description.abstract | The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma
have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Saussurea lappa | en |
dc.subject | Apoptosis | en |
dc.subject | Gastric cancer | en |
dc.subject | p53 | en |
dc.subject | Growth arrest | en |
dc.subject | ATM/ATR | en |
dc.title | Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.contributor.AlternativeAuthor | 고성규 | - |
dc.contributor.AlternativeAuthor | 김황필 | - |
dc.contributor.AlternativeAuthor | 진동훈 | - |
dc.contributor.AlternativeAuthor | 배현수 | - |
dc.contributor.AlternativeAuthor | 김성훈 | - |
dc.contributor.AlternativeAuthor | 박종형 | - |
dc.identifier.doi | 10.1016/j.canlet.2004.06.026 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.