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Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells
Cited 46 time in
Web of Science
Cited 59 time in Scopus
- Authors
- Issue Date
- 2004
- Publisher
- Elsevier
- Citation
- Cancer Letters 220 (2005) 11–19
- Keywords
- Saussurea lappa ; Apoptosis ; Gastric cancer ; p53 ; Growth arrest ; ATM/ATR
- Abstract
- The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma
have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment
resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of
cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts
of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy
with conventional chemotherapy.
- ISSN
- 0304-3835
- Language
- English
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