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Analysis of hepatitis B virus quasispecies distribution in a Korean chronic patient based on the full genome sequences

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dc.contributor.authorKim, Hong-
dc.contributor.authorJee, Young-Mi-
dc.contributor.authorSong, Byung-Cheol-
dc.contributor.authorHyun, Jin-Won-
dc.contributor.authorMun, Ho-Suk-
dc.contributor.authorKim, Hyun-Ju-
dc.contributor.authorOh, Eun-Ju-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorKim, Yoon-Jun-
dc.contributor.authorLee, Hyo-Suk-
dc.contributor.authorHwang, Eung-Soo-
dc.contributor.authorCha, Chang-Yong-
dc.contributor.authorKook, Yoon-Hoh-
dc.contributor.authorKim, Bum-Joon-
dc.date.accessioned2010-01-17T03:12:08Z-
dc.date.available2010-01-17T03:12:08Z-
dc.date.issued2007-01-25-
dc.identifier.citationJ Med Virol. 2007 Mar;79(3):212-9.en
dc.identifier.issn0146-6615 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17245716-
dc.identifier.urihttps://hdl.handle.net/10371/35549-
dc.description.abstractAlthough Korea is a hepatitis B virus (HBV) endemic area, relatively few full-length genome sequences are available. In particular, no comparative analysis has been performed on the full-genome sequences of different HBV quasispecies from a single Korean patient. This report describes the full-length sequences of five HBV clones (two clones with shorter PCR amplicons and three clones with longer amplicons). Large deletions, that is, 685-bp, 487-bp, and 144-bp, that might interfere with the production of normal proteins were observed in four of five clones. Double mutations in the basal core promoter (BCP) region (T1762/A1764) were detected in two clones but no precore mutations (A1896) were detected in any of the five clones. These data support previous results that genotype C, in particular Korean clones of this genotype, is prone to mutations. Two independent mechanisms, namely, the deletions of long lengths and amino acid substitutions followed by BCP double mutations might contribute to the diversity of HBV quasispecies. Considering the importance of HBV quasispecies as HBV variant sources, the distribution of HBV quasispecies in mutation prone genotype C prevalent areas like Korea, should be monitored to improve the management of chronic HBV infections and to control HBV variants that arise due to the administration of vaccine or antiviral therapy.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdulten
dc.subjectDNA, Viral/*geneticsen
dc.subject*Genome, Viralen
dc.subjectHepatitis B Core Antigens/geneticsen
dc.subjectHepatitis B virus/*classification/*genetics/isolation & purificationen
dc.subjectHepatitis B, Chronic/*virologyen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMolecular Sequence Dataen
dc.subjectPhylogenyen
dc.subjectPoint Mutationen
dc.subjectPolymerase Chain Reactionen
dc.subject*Polymorphism, Geneticen
dc.subjectPromoter Regions, Geneticen
dc.subjectSequence Analysis, DNAen
dc.subjectSequence Deletionen
dc.subjectSequence Homologyen
dc.titleAnalysis of hepatitis B virus quasispecies distribution in a Korean chronic patient based on the full genome sequencesen
dc.typeArticleen
dc.contributor.AlternativeAuthor김홍-
dc.contributor.AlternativeAuthor지영미-
dc.contributor.AlternativeAuthor송병철-
dc.contributor.AlternativeAuthor현진원-
dc.contributor.AlternativeAuthor문호숙-
dc.contributor.AlternativeAuthor김현주-
dc.contributor.AlternativeAuthor오은주-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor황응수-
dc.contributor.AlternativeAuthor차창용-
dc.contributor.AlternativeAuthor국윤호-
dc.contributor.AlternativeAuthor김범준-
dc.identifier.doi10.1002/jmv.20789-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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