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Differential expression of vitreous proteins in proliferative diabetic retinopathy

Cited 42 time in Web of Science Cited 47 time in Scopus
Authors
Kim, Sang Jin; Kim, Sangmi; Park, Jungeun; Lee, Hong Kyu; Park, Kyong Soo; Yu, Hyeong Gon; Kim, Youngsoo
Issue Date
2006-03-15
Publisher
Taylor & Francis
Citation
Curr Eye Res. 2006 Mar;31(3):231-40.
Keywords
AgedBiological Markers/metabolismDiabetic Retinopathy/complications/*metabolism/surgeryElectrophoresis, Gel, Two-DimensionalEye Proteins/*metabolismFemaleHumansMaleMass SpectrometryMiddle AgedRetinal Neovascularization/complications/metabolism/surgeryVitrectomyVitreous Body/*metabolism
Abstract
PURPOSE: To identify vitreous proteins that were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization. METHODS: The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two-dimensional gel electrophoresis and mass spectrometry, and the results were compared with those from age-matched patients with macular hole. RESULTS: Twenty-five protein spots were identified in the two-dimensional gel electrophoresis gels. Eight proteins (pigmented epithelium derived factor, serine protease inhibitor, apolipoprotein A-IV precursor, prostaglandin-H2 D-isomerase, a(1)-antitrypsin precursor, ankyrin repeat domain 15 protein, alpha2-HS-glycoprotein, and beta V spectrin) in the 25 spots were expressed significantly differently between the macular hole and proliferative diabetic retinopathy patients (p value < 0.05). Five proteins were upregulated in the proliferative diabetic retinopathy patients, and three were downregulated (p value < 0.05). CONCLUSIONS: We constructed vitreous protein profiles for proliferative diabetic retinopathy patients and identified eight candidate proteins believed to be involved in the pathogenesis of proliferative diabetic retinopathy.
ISSN
0271-3683 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16531280

https://hdl.handle.net/10371/42984
DOI
https://doi.org/10.1080/02713680600557030
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College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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