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The prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype C

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dc.contributor.authorMun, Ho-Suk-
dc.contributor.authorLee, Seoung-Ae-
dc.contributor.authorJee, Youngmee-
dc.contributor.authorKim, Hong-
dc.contributor.authorPark, Joo-Hee-
dc.contributor.authorSong, Byung-Cheol-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorKim, Yoon Jun-
dc.contributor.authorLee, Hyo-Suk-
dc.contributor.authorHyun, Jin-won-
dc.contributor.authorHwang, Eung-Soo-
dc.contributor.authorKim, Bum-Joon-
dc.date.accessioned2010-01-28T07:54:30Z-
dc.date.available2010-01-28T07:54:30Z-
dc.date.issued2008-05-08-
dc.identifier.citationJ Med Virol. 2008 Jul;80(7):1189-94.en
dc.identifier.issn0146-6615 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18461612-
dc.identifier.urihttps://hdl.handle.net/10371/46290-
dc.description.abstractAlthough Korea is one of the endemic areas for hepatitis B virus infection (HBV), the prevalence of deletions in HBV preS region occurring naturally have not been determined. In the present study, the prevalence of preS deletions was determined in terms of clinical state and HBeAg serostatus in 120 patients with different clinical features [59 HBeAg positive, 61 HBeAg negative; 38 asymptomatic carriers, 21 patients with chronic hepatitis, 21 patients with liver cirrhosis, 40 patients with hepatocellular carcinoma (HCC)]. A total of 37 strains (30.8%) harbored deletions in the preS region. Overall, the frequencies of preS deletions tended to increase gradually according to the degree of the clinical severity of liver disease. The prevalence of preS1 deletions in HCC patients tended to be higher than in patients with liver cirrhosis (32.5% vs. 19%). The prevalence of preS2 deletions in HBeAg negative patients was significantly higher than in HBeAg positive patients (23% vs. 6.8%). The type of deletion encountered most frequently was one disrupting the preS1 start codon [14/37 strains (37.8%)], which showed a very high prevalence in HCC patients (9/40, 22.5%; HCC vs. asymptomatic carriers, P=0.048). These results suggest that there might be the discrepancy between preS1 and preS2 mutations in the mechanism of enhancing the progression of chronic liver disease, especially the development of HCC and to maintain tolerance during the stage of immune tolerance. Specific deletion of the type disrupting preS1 start codon may play important roles in hepatocarcinogenesis, at least in Korean patients with chronic HBV infection.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdulten
dc.subjectAmino Acid Sequenceen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectHepatitis B Surface Antigens/chemistry/*geneticsen
dc.subjectHepatitis B virus/classification/*genetics/isolation & purificationen
dc.subjectHepatitis B, Chronic/epidemiology/*virologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMolecular Sequence Dataen
dc.subjectProtein Precursors/chemistry/*geneticsen
dc.subject*Sequence Deletionen
dc.titleThe prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype Cen
dc.typeArticleen
dc.contributor.AlternativeAuthor문호석-
dc.contributor.AlternativeAuthor이승애-
dc.contributor.AlternativeAuthor지영미-
dc.contributor.AlternativeAuthor김홍-
dc.contributor.AlternativeAuthor박주희-
dc.contributor.AlternativeAuthor송병철-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor김윤준-
dc.contributor.AlternativeAuthor이효석-
dc.identifier.doi10.1002/jmv.21208-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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