S-Space College of Medicine/School of Medicine (의과대학/대학원) Molecular and Genomic Medicine (분자유전체의학전공) Journal Papers (저널논문_분자유전체의학전공)
Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus
- Lim, Soo; Choi, Sung Hee; Park, Young Joo; Park, Kyong Soo; Lee, Hong Kyu; Jang, Hak C; Cho, Nam H; Metzger, Boyd E
- Issue Date
- American Diabetes Association
- Diabetes Care. 2007 Feb;30(2):348-53.
- Adipose Tissue/*anatomy & histology; Adult; Blood Glucose/drug effects/metabolism; *Body Composition; Body Mass Index; Diabetes, Gestational/*physiopathology; Female; Glucose Intolerance/*epidemiology; Glucose Tolerance Test; Hemoglobin A, Glycosylated/analysis; Humans; Insulin/blood/pharmacology; Korea/epidemiology; Pregnancy; Risk Factors; Viscera/anatomy & histology
- OBJECTIVE: The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS: A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD(-) women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of +/-1.0 years and +/-1.0 kg/m(2), respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS: One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. beta-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS: High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM.
- 0149-5992 (Print)
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