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Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus

Cited 36 time in Web of Science Cited 36 time in Scopus
Authors
Lim, Soo; Choi, Sung Hee; Park, Young Joo; Park, Kyong Soo; Lee, Hong Kyu; Jang, Hak C; Cho, Nam H; Metzger, Boyd E
Issue Date
2007-01-30
Publisher
American Diabetes Association
Citation
Diabetes Care. 2007 Feb;30(2):348-53.
Keywords
Adipose Tissue/*anatomy & histologyAdultBlood Glucose/drug effects/metabolism*Body CompositionBody Mass IndexDiabetes, Gestational/*physiopathologyFemaleGlucose Intolerance/*epidemiologyGlucose Tolerance TestHemoglobin A, Glycosylated/analysisHumansInsulin/blood/pharmacologyKorea/epidemiologyPregnancyRisk FactorsViscera/anatomy & histology
Abstract
OBJECTIVE: The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS: A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD(-) women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of +/-1.0 years and +/-1.0 kg/m(2), respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS: One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. beta-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS: High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM.
ISSN
0149-5992 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17259506

https://hdl.handle.net/10371/46671
DOI
https://doi.org/10.2337/dc06-1405
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College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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