Browse

Eugenol inhibits K+ currents in trigeminal ganglion neurons

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Li, H. Y; Park, C. K; Jung, S. J; Choi, S. Y; Lee, S. J; Park, K; Kim, J. S; Oh, S. B
Issue Date
2007-09
Publisher
American and International Associations for Dental
Citation
JOURNAL OF DENTAL RESEARCH 86:898-902.
Keywords
eugenoltrigeminal ganglion neuronsvoltage-gated K+ currentsKv1.5
Abstract
Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na+ and Ca^sup 2+^ channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K+ currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch clamping. Eugenol inhibited voltage-gated K+ currents, and the inhibitory effects of eugenol were observed in both capsaicin-sensitive and capsaicin-insensitive neurons. Pre-treatment with capsazepine, a well-known antagonist of TRPV1, failed to block the inhibitory effects of eugenol on K+ currents, suggesting no involvement of TRPV1. Eugenol inhibited human Kv1.5 currents stably expressed in Ltk^sup -^ cells, where TRPV1 is not endogenously expressed. We conclude that eugenol inhibits voltage-gated K+ currents in a TRPV1-independent manner. The inhibition of voltage-gated K+ currents is likely to contribute to the irritable action of eugenol. Abbreviations: human Kv1.5 channel, hKv1.5; transient receptor potential vanilloid 1, TRPV1.
ISSN
0022-0345
Language
English
URI
https://hdl.handle.net/10371/47231
Files in This Item:
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse