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Effects of polychlorinated biphenyl 19 (2,2',6-trichlorobiphenyl) on contraction, Ca2+ transient, and Ca2+ current of cardiac myocytes.

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Issue Date
2001-07
Publisher
Raven Press
Citation
Journal of Cardiovascular Pharmacology 2001;38:11-20.
Keywords
Polychlorinated biphenylContractile forceIntracellular Ca2+concentrationL-type Ca2+ currentHeart cells
Abstract
Polychlorinated biphenyls (PCBs) have been known as serious
environmental pollutants, causing developmental delays, motor dysfunction,
and decrease in brain dopamine level in humans and animals. We have investigated
the effects of a PCB congener, 2,2 ,6-trichlorobiphenyl (PCB 19)
on contractile force, Ca2+ transient, and L-type Ca2+ current (ICa,L) in guinea
pig ventricular myocytes stimulated at a rate of 0.25–0.33 Hz. PCB 19 decreased
contractile force in a concentration-dependent manner. During the
negative inotropic response, the action potential duration at 20% (APD20),
90% of repolarization (APD90), and the action potential amplitude (APA)
were decreased concentration dependently: 30 M PCB 19 reduced APD20,
APD90, and APA by 36.7 ± 3.5%, 22.6 ± 3.9%, and 2.4 ± 0.6%, respectively
(n 11, p < 0.01). PCB 19 30 M decreased the Ca2+ transient and the ICa,L
by 46.8 ± 1.8% (n 9, p < 0.01) and 47.1 ± 3.1% (n 9, p < 0.01),
respectively. The results suggest that PCB 19 decreased the Ca2+ transient
through inhibition of L-type Ca2+ channels and that the decreased Ca2+ transient
consequently caused a negative inotropic effect in cardiac myocytes.
ISSN
0160-2446
Language
English
URI
https://hdl.handle.net/10371/47239
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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