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사람 치은 섬유아세포에서의 Tannerella forsythia 전세균, 막단백질, 당지질에 의한 염증성 사이토카인 발현

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Authors
김정은; 이성훈; 최봉규; 구기태; 김태일; 이용무; 구영; 정종평; 류인철
Issue Date
2008
Publisher
대한치주과학회
Citation
대한치주과학회지 2008;38:543-550.
Keywords
Tannerella forsythiavirulence factorshuman gingival fibroblasts
Abstract
Purpose: The purpose of this study was to investigate induction of cytokine expression in human gingival fibroblasts (HGFs) by whole cell and the components of T. forsythia. Material and Methods: After HGFs were treated with lipopolysaccharide (LPS), membrane protein isolated from T. forsythia or culture media of T. forsythia, the induction of interleukin (IL)-1, IL-6 and IL-8 was examined with real-time PCR and ELISA. Their induction ability of cytokines was compared with whole bacteria. Result: The expression of IL-6 and IL-8 was significantly induced in HGFs by whole bacteria and membrane protein. The expression of IL- was induced by membrane protein of T. forsythia, not by whole bacteria. LPS and condition media of T. forsythia slightly activated HGFs. Conclusion: The membrane protein of T. forsythia could be one of virulence factors.
ISSN
0250-3352
Language
Korean
URI
http://uci.or.kr/G100:I100-KOI(KISTI1.1003/JNL.JAKO200800557080899)

https://hdl.handle.net/10371/47440
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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