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Enhancement of Antithrombogenicity by Urokinase Immobilization on the Gelatin-Adsorbed Polyurethane Surface
항혈전성 향상을 위한 폴리우레탄표면에 대한 젤라틴과 유로키나제의 고정화

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Authors
Ryu, Gyu-Ha; Park, Seon-Yang; Cho, Han-Ik; Min, Byoung-Goo
Issue Date
1989-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.30 No.1, pp. 37-46
Keywords
Urokinase immobilizationGelatinAntithrombogenicity
Abstract
The porous polyurethane (PU) sheet was impregnated with 5% (w/v) gelatin
solution and the fibrinolytic enzyme to promote the antithrombogenicity of artificial ventricle's
surface. Urokinase was immobilized on the gelatin-treated surface with 0.45% (w/v)
buffered glutaraldehyde solution (pH 7.4). The coagulation time was delayed to 1.2 times in
the gelatin-urokinase co-immobilized surface than the nonporous PU control by APTT
measurement.
By urokinase immobilization, the maximal activities of the enzyme were elongated (from 2
hour to 4 hour). In vitro study shows that the antithrombogenicity was improved after gelatin
adsorption and urokinase immobilization on the polyurethane.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/5533
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 30 No.1 (1989)
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