Effect of Red Pepper and Bracken Fern on GastroduodenaI Carcinogenesis in Wistar Rats Induced by N-MethyI-N'-nitro-N-nitrosoguanidine

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Park, Kyung-Hwan; Kim, Jin-Pok

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Seoul National University College of Medicine
Seoul J Med, Vol.34 No.2, pp. 117-125
Chemical carcinogenesisMNNGRed pepperBracken fern
Epidemiologic and experimental studies have shown that gastric
carcinogenesis is strongly associated with dietary habits. This experiment was
performed to analyze the effects of red pepper and bracken fern on
gastroduodenal carcinogenesis by N-methyl-N' -nitro-N-nitrosoguanidine (MNNG)
in vivo. Male Wistar rats were divided into 6 groups: control group (A), red
pepper only treated group (8), bracken fern only treated group (C), MNNG only
treated group (0), MNNG and red pepper treated group (E) and MNNG and
bracken fern treated group (F). The control group was supplied with a normal
diet and distilled water. MNNG was given at a concentration of 100 Jig/ml in
distilled water for 0, E and F groups, supplemented with 3% red pepper for E
group and supplemented with 5% bracken fern for F group. Three percent red
pepper in diet was given to 8 group and five percent bracken fern in diet was
given to C group. These diet regimens were given ad libitum continuously for 40
weeks. Histopathological examination was performed after 40 weeks of
experiment. Tumors occurred only in MNNG administered groups. There were no
differences in the occurrence rates of adenocarcinoma of the glandular stomach
between 0, E and F group (78.3%, 70.8%, 73.9%). There was a significantly
higher occurrence rate of adenocarcinoma of the duodenum in E and F groups
(41.7%, 30.4%) than in the 0 group (4.3%) (P<0.05). These results suggest that
red pepper and bracken fern have a promoting effect on duodenal carcinogenesis
by MNNG.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.2 (1993)
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