Browse

Signet Ring Cell Carcinoma of the Stomach in N-methyl-N'nitro-N-nitrosoguanidine-Administered Rats. Report of Two Cases with Special Reference to Its Histogenesis
N-methyl-N'-Nitrosoguanidine 투여에 의하여 발생한 흰쥐 위의 인환세포암종.선와상피세포로부터의 조직발생을 시사하는 2 증례보고

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Kim, Yong Il; Kim, Woo Ho; Han, Duck Jong
Issue Date
1987-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.28 No.1, pp. 10-15
Keywords
Experimental gastric carcinomaSignet ring cell carcinomaN-methyl-N'-nitro-N-nitrosoguanidine
Abstract
Sprague-Dawley rats, orally administered with N-methyl-N'-nitro-N-nitrosoguanidine
(100 ,u glml dissolved in drinking water given ad libitum) for 28 weeks were sacrificed
12 weeks after the last administration. Of 89 neoplastic lesions from 96 rats, two rats
developed signet ring cell carcinoma (SRC) with focal mixture of poorly differentiated adenocarcinoma
in one, involving the full thickness of the gastric wall and blood vessels. Aside from
the incipient atypical cell growth along the foveolar epithelium there was a histochemical
similarity of mucin between SRC and atypical foveolar epithelial cells. These observations
suggest that SRC develops from non-metaplastic foveolar epithelium of the stomach.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/5692
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.1 (1987)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse