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Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients

Cited 16 time in Web of Science Cited 17 time in Scopus
Authors
Song, Eun Young; Park, Soyun; Lee, Dong Soon; Cho, Han Ik; Park, Myoung Hee
Issue Date
2008-06-24
Publisher
Elsevier
Citation
Hum Immunol. 2008 Jun;69(6):354-9. Epub 2008 May 16.
Keywords
AdolescentAdultAgedAged, 80 and overAnemia, Aplastic/blood/*genetics/immunology/physiopathology*Asian Continental Ancestry GroupChildChild, PreschoolFemale*Gene FrequencyGenetic Predisposition to DiseaseHLA-DR Antigens/blood/*genetics/immunologyHumansInfantKoreaMaleMiddle AgedSeverity of Illness Index
Abstract
Although association of human leukocyte antigen (HLA)-DR2 (DRB1*1501) with susceptibility to aplastic anemia (AA) has been well documented in several different ethnic groups, little is known about the protective role of HLA in this disease. HLA-DRB1 alleles were analyzed in 109 Korean AA patients (26 nonsevere and 83 severe) and 800 healthy controls. The frequency of DRB1*1501 was significantly higher in AA patients compared with controls [33.0% vs 15.3%, p=0.000004, p(c)=0.0001, odds ratio (OR)=2.74]. Nonsevere AA (30.8%, OR=2.47) and severe AA patients (33.7%, OR=2.83) showed similar changes, and DRB1*1501 was considered a susceptibility factor to AA in both forms of the disease. The frequency of DRB1*1302 in total AA patients was not different from controls (12.8% vs 17.9%), but it was significantly lower in severe AA compared with nonsevere AA patients (6.0% vs 34.6%, p=0.0006, p(c)=0.02, OR=0.12). DRB1*1302 was considered a protective factor against severe AA. In Koreans, DRB1*1501 was associated with disease susceptibility to AA and DRB1*1302 with protection against the severe form of the disease.
ISSN
0198-8859 (Print)
0198-8859 (Linking)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18571007

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http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T3B-4SHN8P7-1-1&_cdi=4942&_user=168665&_orig=search&_coverDate=06%2F30%2F2008&_sk=999309993&view=c&wchp=dGLbVtb-zSkzk&md5=96e004255e8e5a5e27f7eb0a05c0fdfe&ie=/sdarticle.pdf

http://hdl.handle.net/10371/58515
DOI
https://doi.org/10.1016/j.humimm.2008.04.009
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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