S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Chemical and Biological Engineering (화학생물공학부) Journal Papers (저널논문_화학생물공학부)
Dual-Functionalized Polymer Nanotubes as Substrates for Molecular-Probe and DNA-Carrier Applications
- Jang, Jyongsik; Ko, Sungrok; Kim, Younggeun
- Issue Date
- Adv. Funct. Mater. 2006, 16, 754–759
- Bifunctionalized polymer nanotubes have been fabricated using vapor-deposition polymerization in FeCl3-adsorbed anodic aluminum
oxide membranes followed by attachment of amine-functionalized silica nanoparticles. The prepared bifunctionalized
polymer nanotubes are applied as both a molecular probe and a DNA carrier by conjugating pyreneacetic acid with the amine
groups and immobilizing DNA with the carboxylic acid groups on the surface. The number of amine functional groups on the
nanotubes surface can be measured by means of the photoluminescence intensity of pyreneacetic acid conjugated with amine
groups, and the number of the residual carboxylic acid groups is calculated by titration with sodium hydroxide. Fourier-transform
infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, scanning electron microscopy,
and confocal laser scanning microscopy have been performed to confirm the complete polymerization of the monomer and the
attachment of photoluminescent molecules and single-stranded DNA.
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