S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea
- Park, Su Cheol; Jeong, Sook-Hyang; Kim, Jin; Han, Chul Ju; Kim, You Cheoul; Choi, Kui Sung; Cho, Jang Hyun; Lee, Myoungjin; Jung, Ha Hyun; Ki, Seung Seog; Chang, Yoon Hwan; Lee, Seung Sook; Park, Yeon Hee; Lee, Kee Ho
- Issue Date
- J Med Virol. 2008 ;80(6):960-6.
- Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; DNA, Viral/analysis; Female; Genes, Viral/genetics; Hepatitis B/*complications/*epidemiology; Hepatitis B Core Antigens/analysis; Hepatitis B Surface Antigens/analysis; Hepatitis B virus/genetics/isolation & purification; Hepatitis C/epidemiology; Humans; Immunohistochemistry; Korea/epidemiology; Leukocytes, Mononuclear/virology; Lymphoma, B-Cell/*complications/epidemiology/virology; Lymphoma, Non-Hodgkin/*complications/epidemiology/virology; Male; Middle Aged; Prevalence; Stomach Neoplasms/complications/epidemiology
- This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible role for HBV in the development of non-Hodgkin's lymphoma.
- 0146-6615 (Print)
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