Publications
Detailed Information
Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population
Cited 23 time in
Web of Science
Cited 24 time in Scopus
- Authors
- Issue Date
- 2007-10-05
- Publisher
- Elsevier
- Citation
- Diabetes Res Clin Pract. 2008 ;79(2):284-90.
- Keywords
- Aged ; Chromosome Mapping ; Diabetes Mellitus, Type 2/enzymology/epidemiology/*genetics ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Insulysin/*genetics ; Korea/epidemiology ; Male ; Middle Aged ; Reference Values ; Risk Assessment ; Chromosomes, Human, Pair 10 ; Polymorphism, Single Nucleotide
- Abstract
- Insulin-degrading enzyme (IDE) is a metalloproteinase which degrades insulin and terminates its action. Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a rat model of type 2 diabetes mellitus. Several genetic association studies examined IDE as a susceptibility gene for type 2 diabetes in European descents. Here we investigated the genetic association of IDE polymorphisms with the risk of type 2 diabetes and its related phenotypes in the Korean population. Among six single nucleotide polymorphisms analyzed, g.-179T>C (OR=1.73, P=0.04), and g.IVS18+99G>A (OR=1.23, P=0.02) revealed borderline association with increased risk of type 2 diabetes. Combining our results with previous data obtained from the European population, g.-179T>C (OR=1.11, P=0.03), and g.IVS24-64A>T (OR=1.18, P=0.005) showed significant association with type 2 diabetes. Haplotype consisting of common alleles of the six polymorphisms was associated with decreased risk of type 2 diabetes (OR=0.82, P=0.02). However, none of the polymorphisms was significantly associated with metabolic phenotypes. We can conclude that variations in IDE might contribute to diabetes susceptibility in the Korean population.
- ISSN
- 1872-8227 (Electronic)
- Language
- English
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.