S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer
- Lee, Sang Hyub; Ryu, Ji Kon; Lee, Kyeung-Yeup; Woo, Sang Myung; Park, Joo Kyung; Yoo, Ji Won; Kim, Yong-Tae; Yoon, Yong Bum
- Issue Date
- Cancer Lett. 2008 ;259(1):39-49.
- Animals; Antimetabolites, Antineoplastic/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/*pharmacology/therapeutic use; Apigenin/administration & dosage; Apoptosis/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Deoxycytidine/administration & dosage/analogs & derivatives; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Humans; Mice; NF-kappa B/metabolism; Pancreatic Neoplasms/*drug therapy/metabolism/pathology; Proto-Oncogene Proteins c-akt/metabolism; Xenograft Model Antitumor Assays; bcl-2-Associated X Protein/metabolism
- Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction.
- 0304-3835 (Print)
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