Browse

Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

Cited 83 time in Web of Science Cited 95 time in Scopus
Authors
Lee, Sang Hyub; Ryu, Ji Kon; Lee, Kyeung-Yeup; Woo, Sang Myung; Park, Joo Kyung; Yoo, Ji Won; Kim, Yong-Tae; Yoon, Yong Bum
Issue Date
2007-10-31
Publisher
Elsevier
Citation
Cancer Lett. 2008 ;259(1):39-49.
Keywords
AnimalsAntimetabolites, Antineoplastic/administration & dosageAntineoplastic Combined Chemotherapy Protocols/*pharmacology/therapeutic useApigenin/administration & dosageApoptosis/drug effectsCell Line, TumorCell Proliferation/drug effectsDeoxycytidine/administration & dosage/analogs & derivativesDose-Response Relationship, DrugDown-RegulationDrug SynergismHumansMiceNF-kappa B/metabolismPancreatic Neoplasms/*drug therapy/metabolism/pathologyProto-Oncogene Proteins c-akt/metabolismXenograft Model Antitumor Assaysbcl-2-Associated X Protein/metabolism
Abstract
Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction.
ISSN
0304-3835 (Print)
Language
English
URI
https://hdl.handle.net/10371/62320
DOI
https://doi.org/10.1016/j.canlet.2007.09.015
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse