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Computer-aided detection in full-field digital mammography: sensitivity and reproducibility in serial examinations

Cited 32 time in Web of Science Cited 39 time in Scopus
Authors
Kim, Seung Ja; Moon, Woo Kyung; Cho, Nariya; Cha, Joo Hee; Kim, Sun Mi; Im, Jung-Gi
Issue Date
2007-12-22
Publisher
Radiological Society of North America (RSNA)
Citation
Radiology. 2008 ;246(1):71-80.
Keywords
AdultAgedAged, 80 and overBreast Neoplasms/pathology/*radiography*Diagnosis, Computer-AssistedFemaleHumansMammography/*methodsMiddle Aged*Radiographic Image EnhancementRetrospective StudiesSensitivity and Specificity
Abstract
PURPOSE: To retrospectively evaluate the sensitivity and reproducibility of a computer-aided detection (CAD) system applied to serial digital mammograms obtained in women with breast cancer, with histologic analysis as the reference standard. MATERIALS AND METHODS: This study was institutional review board approved, and patient informed consent was waived. A commercially available CAD system was applied to initial and follow-up digital mammograms obtained in 93 women with breast cancer (mean age, 52 years; age range, 32-81 years). The mean interval between mammographic examinations was 23 days (range, 7-58 days). There were 119 visible lesion components (70 masses, 49 microcalcifications). Sensitivity, false-positive mark rate, and reproducibility of the CAD system were evaluated for both sets of mammograms with the t test. RESULTS: Sensitivities of the CAD system at initial and follow-up digital mammography were 91% and 89%, respectively, for detection of masses. Sensitivity of the CAD system for detection of microcalcifications was 100% at both initial and follow-up digital mammography. Overall false-positive mark rates were 0.29 per image and 0.27 per image at initial and follow-up digital mammography, respectively. When craniocaudal and mediolateral oblique views were considered separately, sensitivities were 76% and 75%, respectively, for masses and 96% and 92%, respectively, for microcalcifications. The reproducibility of CAD marks was 80% for true-positive masses, 92% for true-positive microcalcifications, 9% for false-positive masses, and 8% for false-positive microcalcifications (P < .001). CONCLUSION: The sensitivity of the CAD system was consistently high for detection of breast cancer on initial and short-term follow-up digital mammograms. Reproducibility was significantly higher for true-positive CAD marks than for false-positive CAD marks. SUPPLEMENTAL MATERIAL: http://radiology.rsnajnls.org/cgi/content/full/246/1/71/DC1.
ISSN
1527-1315 (Electronic)
0033-8419 (Print)
Language
English
URI
http://radiology.rsna.org/content/246/1/71.full.pdf

https://hdl.handle.net/10371/62411
DOI
https://doi.org/10.1148/radiol.2461062072
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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