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Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Kang, Hio Chung; Kim, Il-Jin; Jang, Sang-Geun; Hong, Seung-Hyun; Hwang, Jung-Ah; Shin, Hai-Rim; Park, Jae-Gahb
Issue Date
2007-12-15
Publisher
Elsevier
Citation
Cancer Lett. 260 (2007) 170-179
Keywords
Case-Control StudiesCell Cycle Proteins/*geneticsColorectal Neoplasms/*genetics/pathology*Gene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHaplotypesMicrosatellite InstabilityMitosis/*geneticsNeoplasm MetastasisNeoplasm Proteins/*geneticsNeoplasm StagingOdds RatioPhenotype*Polymorphism, Single NucleotideRisk AssessmentRisk Factors
Abstract
CHFR was recently identified as an early mitotic checkpoint that delays transition to metaphase in response to mitotic stress. Although studies have shown that CHFR is relevant to tumorigenesis, no previous report has investigated whether polymorphisms in the CHFR gene are associated with the risk of cancer development. Here, we genotyped polymorphisms in the CHFR gene and analyzed the possible associations of single polymorphisms and haplotypes with the risk and clinicopathological characteristics of colorectal cancer. Six coding SNPs in the CHFR gene were genotyped in 462 colorectal cancer patients and 245 healthy normal controls, using either the TaqMan assay or direct sequencing. Our results revealed that the V539M polymorphism was significantly associated with a lower risk of colorectal cancer (P=0.03; OR, 0.533; 95% CI, 0.302-0.94), and significantly correlated with no distant metastasis (M0 stage), different TNM stage, and microsatellite instability (MSI) among the colorectal cancer patients. Among the five tested haplotypes, hap 10 (TGACTA) was significantly associated with a lower risk of colorectal cancer (P=0.017; OR, 0.496; 95% CI, 0.279-0.883), and colorectal cancer patients carrying this haplotype showed no distant metastasis, different TNM stage, and microsatellite instability at a significantly higher frequency. These results reveal for the first time that polymorphisms in the CHFR gene are associated with colorectal cancer susceptibility.
ISSN
0304-3835 (Print)
Language
English
URI
http://hdl.handle.net/10371/62537
DOI
https://doi.org/10.1016/j.canlet.2007.10.036
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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