금붕어의 안구돌출에 관한 실험적 연구

Abstract

Gold fish (Carassius auratus, var. japonicus) were used for the demonstration of the exophthalmos-producing substance in the serum of a patient suffering from thyrotoxicosis with exophthalmos. The exophthalmic response of the fish was determined by measuring the intercorneal distance by the use of a micrometer before and after the injections of test materials, and the percentage change in that distance was calculated. The responsiveness of the fish was partly controlled by the injections of normal saline. normal human serum. and commercially prepared anterior pituitary hormone with and without prednisolone added. The normal saline injection did not provoke any resonse in fish. The normal human serum produced transient enophthalmos. whereas the serum from a patient suffering from toxic goiter with exophthalmos produced definite exophthalmos. The anterior pituitary hormone elicited marked exophthalmic response. There was no correlation between the degree of response and the dosage level of the hormone used. Addition of prednisolone to this hormone preparation seemed to inhibit the exophthalmogenic effect of the anterior pituitary hormone. This method of the production of experimental exophthalmos in gold fish might be used for the demonstration of the exophthalmos-producing substance in the serum of the exophthalmic patient.