Browse

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Cited 17 time in Web of Science Cited 16 time in Scopus
Authors
Lee, Kyoung-Ho; Vermeulen, Roel; Lenters, Virissa; Cho, Soo-Hun; Strickland, Paul T; Kang, Daehee
Issue Date
2008-11-21
Publisher
Springer Verlag
Citation
Int Arch Occup Environ Health. 2009 ;82(8):961-8.
Keywords
AdolescentCarcinogens, Environmental/adverse effects/metabolismChildCookery/methodsCotinine/urineDiet/adverse effectsEnvironmental Exposure/*adverse effectsFemaleGlucuronates/*urineHumansKoreaMalePolycyclic Hydrocarbons, Aromatic/adverse effects/metabolismPyrenesQuestionnairesTobacco Smoke Pollution/adverse effects
Abstract
OBJECTIVES: This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children. METHODS: Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires. RESULTS: Mean (+/-SE) 1-OHPG levels were 1.64 (+/-0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home. CONCLUSIONS: These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.
ISSN
1432-1246 (Electronic)
0340-0131 (Print)
Language
English
URI
https://hdl.handle.net/10371/63007
DOI
https://doi.org/10.1007/s00420-008-0385-2
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse