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Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyoung-Ho | - |
dc.contributor.author | Vermeulen, Roel | - |
dc.contributor.author | Lenters, Virissa | - |
dc.contributor.author | Cho, Soo-Hun | - |
dc.contributor.author | Strickland, Paul T | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2010-04-13 | - |
dc.date.available | 2010-04-13 | - |
dc.date.issued | 2008-11-21 | - |
dc.identifier.citation | Int Arch Occup Environ Health. 2009 ;82(8):961-8. | en |
dc.identifier.issn | 1432-1246 (Electronic) | - |
dc.identifier.issn | 0340-0131 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/63007 | - |
dc.description.abstract | OBJECTIVES: This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children. METHODS: Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires. RESULTS: Mean (+/-SE) 1-OHPG levels were 1.64 (+/-0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home. CONCLUSIONS: These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adolescent | en |
dc.subject | Carcinogens, Environmental/adverse effects/metabolism | en |
dc.subject | Child | en |
dc.subject | Cookery/methods | en |
dc.subject | Cotinine/urine | en |
dc.subject | Diet/adverse effects | en |
dc.subject | Environmental Exposure/*adverse effects | en |
dc.subject | Female | en |
dc.subject | Glucuronates/*urine | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Polycyclic Hydrocarbons, Aromatic/adverse effects/metabolism | en |
dc.subject | Pyrenes | en |
dc.subject | Questionnaires | en |
dc.subject | Tobacco Smoke Pollution/adverse effects | en |
dc.title | Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이경호 | - |
dc.contributor.AlternativeAuthor | 조수헌 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1007/s00420-008-0385-2 | - |
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