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Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children
Cited 19 time in
Web of Science
Cited 17 time in Scopus
- Authors
- Issue Date
- 2008-11-21
- Publisher
- Springer Verlag
- Citation
- Int Arch Occup Environ Health. 2009 ;82(8):961-8.
- Keywords
- Adolescent ; Carcinogens, Environmental/adverse effects/metabolism ; Child ; Cookery/methods ; Cotinine/urine ; Diet/adverse effects ; Environmental Exposure/*adverse effects ; Female ; Glucuronates/*urine ; Humans ; Korea ; Male ; Polycyclic Hydrocarbons, Aromatic/adverse effects/metabolism ; Pyrenes ; Questionnaires ; Tobacco Smoke Pollution/adverse effects
- Abstract
- OBJECTIVES: This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children. METHODS: Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires. RESULTS: Mean (+/-SE) 1-OHPG levels were 1.64 (+/-0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home. CONCLUSIONS: These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.
- ISSN
- 1432-1246 (Electronic)
0340-0131 (Print)
- Language
- English
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