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Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk

Cited 101 time in Web of Science Cited 108 time in Scopus
Issue Date
2008-08-12
Publisher
Elsevier
Citation
Leuk Res. 2009 ;33(2):250-8.
Keywords
AdolescentCase-Control StudiesChildChild, PreschoolCytochrome P-450 CYP1A1/*geneticsEnvironmental ExposureFemaleGenotypeHaplotypesHumansInfantLeukemia/*etiologyMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsSmoking/*adverse effectsFathersPolymorphism, Genetic
Abstract
We conducted a case-control study to evaluate the association between paternal smoking and childhood leukemia and to evaluate potential modification by polymorphisms in CYP1A1. Histologically confirmed childhood leukemia cases (n=164) and non-cancer controls (n=164) were recruited from three teaching hospitals in Seoul, Korea. Five single nucleotide polymorphisms in CYP1A1 (-17961T>C, -9893G>A, I462V, 1188C>T (*2A), and 11599C>G) were genotyped and haplotypes were estimated by the expectation-maximization method. We also conducted a meta-analysis of 12 studies that have reported the association between paternal smoking and childhood leukemia risk. Paternal smoking at home was associated with all leukemias (OR=1.8, 95% CI=1.1-2.8) and acute lymphoblastic leukemia (ALL) (2.0, 1.2-3.4). An increasing trend in risk was observed for pack-years smoked after birth (P(trend)=0.06 and 0.02, respectively) and the number of smokers in the home during the child's life (P(trend)=0.05 and 0.03, respectively). Among those without the CGACC haplotype, ALL risk was significantly increased by the father's smoking at home (2.8, 1.5-5.3) and the presence of at least one smoker in the home (2.3, 1.2-4.4), and the test for interaction was significant (P(interaction)=0.03 and 0.02, respectively). The meta-analysis showed that overall paternal smoking (1.13, 1.04-1.24) and smoking before the pregnancy of the child (1.12, 1.04-1.21) were significantly associated with childhood leukemia risk. Our results suggest that paternal smoking is a risk factor for childhood leukemia and the effect may be modified by CYP1A1 genotype.
ISSN
1873-5835 (Electronic)
0145-2126 (Print)
Language
English
URI
https://hdl.handle.net/10371/63011
DOI
https://doi.org/10.1016/j.leukres.2008.06.031
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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