S-Space College of Medicine/School of Medicine (의과대학/대학원) Preventive Medicine (예방의학전공) Journal Papers (저널논문_예방의학전공)
Facial wrinkles as a predictor of decreased renal function
- Park, Byung-Hyun; Lee, Sik; Park, Jin-Woo; Kim, Kyung-Ah; Kim, Han-Uk; Lee, Ju-Hyung; Koh, Dai-Ha; Youm, Jung-Ho; Yoo, Nina; Park, Sue-Kyung; Kwon, Keun-Sang
- Issue Date
- Nephrology (Carlton). 2008 ;13(6):522-7.
- Adult; Age Factors; Aged; Aged, 80 and over; Cross-Sectional Studies; Face; Female; *Glomerular Filtration Rate; Humans; Male; Middle Aged; *Skin Aging
- AIMS: Oxidative stress generated either by exogenous or endogenous sources can lead to progressive organ damage and skin ageing over a long period of time. Moreover, some dermatological signs are independent of chronological ageing, and may reflect the long-term redox state of internal organs. Therefore, we hypothesized that there might be an association between facial wrinkles and decreased renal function, an oxidative stress-related disease. METHODS: A cross-sectional study was carried out in a Korean population of 264 adults aged 30 years and older. Facial wrinkle scores in the crow's-foot area were estimated using a standardized form of visual assessment. As an index of renal function, we determined estimated glomerular filtration rate (eGFR). Lipid hydroperoxide (LPO) assay was performed to measure the levels of oxidative stress. RESULTS: After adjusting for possible confounders, lower eGFRs and higher LPO levels were found in those with severe facial wrinkles. CONCLUSION: We conclude that severe facial wrinkles might be used as a predictive marker of decreased renal function, independently of age, gender and other established risk factors.
- 1440-1797 (Electronic)
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