Effects of bisphenol A on breast cancer and its risk factors

Cited 107 time in Web of Science Cited 113 time in Scopus

Yang, Mihi; Ryu, Jae-Ha; Jeon, Raok; Kang, Daehee; Yoo, Keun-Young

Issue Date
Springer Verlag
Arch Toxicol. 2009 ;83(3):281-5.
AdultBreast Neoplasms/*etiologyCase-Control StudiesDose-Response Relationship, DrugEndocrine Disruptors/blood/*pharmacologyFemaleHumansMiddle AgedPhenols/blood/*pharmacologyRisk Factors
The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We studied potential associations between BPA exposure and breast cancer risks in Korean women by performing biomonitoring of BPA among breast cancer patients and controls (N = 167). Blood samples were collected between 1994 and 1997 and kept over 10 years in a freezer under well controlled conditions. The blood BPA levels determined by HPLC/FD, ranged between LOD (0.012 microg/L) and 13.87 microg/L (mean +/- SD, 1.69 +/- 2.57 microg/L; median, 0.043 microg/L). In age-matched subjects (N = 152), there were some associations between BPA levels and risks of breast cancer, such as age at first birth and null parity. However, there were no significant differences in blood BPA levels between the cases and the controls (P = 0.42). Considering interactions between BPA exposure and risks of breast cancer, we suggest further enlarged biomonitoring studies of BPA to provide effective prevention against breast cancer.
1432-0738 (Electronic)
0340-5761 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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