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Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole

Cited 33 time in Web of Science Cited 38 time in Scopus
Authors
Kwon, Jun Soo; Kim, Euitae; Kang, Do-Hyung; Choi, Jung Seok; Yu, Kyung-Sang; Jang, In-Jin; Shin, Sang-Goo
Issue Date
2008-09-13
Publisher
Elsevier
Citation
Eur Neuropsychopharmacol. 2008 ;18(12):897-907.
Keywords
AdolescentAdultAgedAntidepressive Agents/therapeutic useAntipsychotic Agents/*therapeutic useDouble-Blind MethodFemaleFollow-Up StudiesGenotypeHumansMaleMiddle AgedPiperazines/*therapeutic use*Polymorphism, GeneticProlactin/bloodProspective StudiesPsychiatric Status Rating Scales*Psychotic Disorders/drug therapy/genetics/physiopathologyQuinolones/*therapeutic useReceptors, Dopamine D2/*genetics*Schizophrenia/drug therapy/genetics/physiopathologyYoung Adult
Abstract
We investigated whether the clinical response to aripiprazole differed according to the Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene. In this 26-week, prospective, open-label, double-blind, parallel-group study, 90 patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder were recruited and divided into two groups according to their DRD2 genotype (A1A1, n=14; A1A2+A2A2, n=76). The efficacy assessment included Positive and Negative Syndrome Scale (PANSS) scores and Clinical Global Impression (CGI) scores. Extrapyramidal symptoms were assessed using the Simpson-Angus Scale (SAS), Abnormal Involuntary Movement Scale (AIMS), and Barnes Akathisia Rating Scale (BAS). Plasma prolactin levels were also measured. Patients with the A1A1 genotype showed a more favorable therapeutic response to aripiprazole when assessed using the PANSS ratio. The changes in the SAS score from baseline to week 4 also differed according to the genotype group. There were no significant differences in the changes in the CGI, AIMS, and BAS scores or plasma prolactin level between the two genotype groups. The results suggest an association between the DRD2 Taq1A polymorphism status and the variation in the clinical response to aripiprazole.
ISSN
0924-977X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18786813

http://hdl.handle.net/10371/63330
DOI
https://doi.org/10.1016/j.euroneuro.2008.07.010
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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