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Observation of Liver Pathology after Praziquantel Treatment in Experimental Clonorchis sinensis Infection in Guinea Pigs
간흡충 감염 Guinea pig에 있어서 프라지콴텔 투여후 간병변 치유여부에 대한 관찰

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Authors
Lee, Soon-Hyung; Chai, Jong-Yil; Yang, Eue-Cho; Yun, Chong Ku; Hong, Sung-Tae; Lee, Jung Bin
Issue Date
1988-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.29 No.3, pp. 253-262
Keywords
Clonorchis sinensisLiver flukePraziquantelGuinea pigBile duct
Abstract
The liver of guinea pigs infected experimentally with Clonorchis sinensis was
grossly and histologically examined after treatment with praziquanteL Total 38 male guinea
pigs were infected each with 300-500 metacercariae. Five weeks later praziquantel treatment
was done on 28 animals, and repeated if needed. Remaining 10 were used for untreated
controls, while 3 others were for uninfected controls. Liver examinations were done at 1, 2,
4 and/or 9 weeks following the treatment.
Compared with uninfected controls, C sinensis-infected guinea pigs grossly revealed remarkably
enlarged and swollen liver, with yellowish discolorations at surrounding portions of
infected sites. Histologically these livers showed cystic hyperplasia of the bile ducts accompanied
by irregular dilatation, glandular and/or papillary hyperplasia of the lining epithelia as
well as periductal fibrosis.
The livers of praziquantel-treated animals grossly revealed more of less recovering features
later than 2 weeks after the treatment. Histologically, although adenomatous hyperplasia was
quite subsided, other bile duct changes such as cystic hyperplasia and fibrosis were persistently
retained in most animals until 9 weeks after the treatment. The results suggest that the
liver damage induced by C sinensis is persistent for at least a few months after deworming
with praziquantel.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/6391
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 29 No.3 (1988)
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