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Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches
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- Authors
- Issue Date
- 2006-01-18
- Publisher
- Elsevier
- Citation
- Experimental and Toxicologic Pathology 2006;57:321–328
- Keywords
- Mucositis ; GM-CSF ; 5-FU ; Hamster buccal pouch ; Immunohistochemistry
- Abstract
- The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 μg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
- ISSN
- 0940-2993
http://dx.doi.org/10.1016/j.etp.2005.09.006
- Language
- English
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