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Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice

Cited 214 time in Web of Science Cited 235 time in Scopus
Authors
Lee, Hui-Young; Park, Jong-Hwan; Seok, Seung-Hyeok; Baek, Min-Won; Kim, Dong-Jae; Lee, Ki-Eun; Paek, Kyung-Soo; Lee, Yeonhee; Park, Jae Hak
Issue Date
2006-05-20
Publisher
Elsevier
Citation
Biochim Biophys Acta. 1761 (2006) 736–744
Keywords
Conjugated linoleic acidLactobacillus rhamnosusDiet induced obeseAnti-obesityMouse
Abstract
Many previous studies have reported that conjugated linoleic acid could be produced by starter culture bacteria, but the effects of the bacteria were not investigated. Moreover, there was no evidence of the conjugated linoleic acid-producing bacteria having potential health or nutritional effects related to conjugated linoleic acid, including reducing body fat. Here, we investigated the anti-obesity effect of Lactobacillus rhamnosus PL60, a human originated bacterium that produces t10, c12-conjugated linoleic acid, on diet-induced obese mice. After 8 weeks of feeding, L. rhamnosus PL60 reduced body weight without reducing energy intake, and caused a significant, specific reduction of white adipose tissue (epididymal and perirenal). Although the size of epididymal adipocytes was not reduced by L. rhamnosus PL60, apoptotic signals and UCP-2 mRNA levels increased in adipose tissue. Liver steatosis, a well known side effect of CLA, was not observed by L. rhamnosus PL60 treatment; on the contrary it seemed to be normalized. Results showed that the amount of conjugated linoleic acid produced by Lactobacillus rhamnosus PL60 was enough to produce an anti-obesity effect.
ISSN
1388-1981
Language
English
URI
http://hdl.handle.net/10371/6474
DOI
https://doi.org/10.1016/j.bbalip.2006.05.007
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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