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Carcinoembryonic Antigen (CEA) in N-methyl-N'-nitro-N-nitrosoguanidine-Induced Gastrointestinal Carcinomas of the Rats : N-methyl-N'-nitro-N-nitrosoguanidine 투여에 의한 실험적 상부 소화관 암종의 암태생항원 발현에 관한 면역조직화학적 관찰
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- Authors
- Issue Date
- 1987-12
- Citation
- Seoul J Med, Vol.28 No.4, pp. 297-301
- Keywords
- N-methyl-N'-nitro-N-nitrosoguanidine ; Experimental carcinoma ; Gastrointestinal carcinoma ; Immunohistologic carcinoembryonic antigen
- Abstract
- Immunohistologic findings on carcinoembryonic antigen (CEA) and its serum
level were compared in N-methyl-N' -nitro-N-nitrosoguanidine (MNNG)-induced gastrointestinal
malignant tumors. Of fifty-six malignant neoplastic lesions developed from 39 rats, only
10 carcinomas were CEA positive (10.7% of gastric and 31.8% of small intestinal cancers) in
cytoplasm of tumor cells by peroxidase-antiperoxidase (PAP) staining method. Animals with
CEA positive carcinoma showed the highest level of serum CEA than any other groups, but
the difference was not statistically significant (0.964 ± 0.150 versus 0.883 ±0.094). The
above findings lead to the suggestion that experimental gastric carcinoma expresses lower CEA
positivity than intestinal carcinoma, comparatively similar to the reported results in human
cases.
- ISSN
- 0582-6802
- Language
- English
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