S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 28 No.4 (1987)
Effect of Corticosterone on the Serotonin Receptor Binding Properties in Rat Cerebral Cortex
Corticosterone이 흰쥐 대뇌피질 serotonin 수용체 결합성에 미치는 영향에 관한 연구
- Park, Sung Woo; Suh, Yoo Hun; Woo, Jong Inn; Park, Chan-Woong
- Issue Date
- Seoul J Med, Vol.28 No.4, pp. 303-309
- A possible role of brain serotonin in the regulation of HPA axis activity including
feed-back sensitivity has been studied by many investigators.
The present study was undertaken to check the serotonin binding to rat cerebral cortex
membrane before and after corticosterone replacement in adrenalectomized rats.
Both the affinity and the number of serotonin binding sites were significantly increased
following corticosterone replacement, compared to those of adrenalectomized control.
In conclusion, the present study strongly suggests that cerebral cortical serotonin receptor
sensitivity might be changed by repeated treatment with corticosterone and may support the
assumption of serotoninergic regulation in feed-back activity of HPA axis.