Publications
Detailed Information
FLEX-FIT: A Flexible Bayesian Forecasting Program for Dosage Optimization in Clinical Pharmacokinetics : Flex-Fit: Bayesian 원리에 기초한 적정요양 결정을 위한 컴퓨터 프로그램
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 1987-12
- Citation
- Seoul J Med, Vol.28 No.4, pp. 311-319
- Keywords
- Computer program ; Bayesian theorem ; Simplex method ; Non-linear least square ; Pharmacokinetics ; One- or two- compartmental model ; Dosage optimization
- Abstract
- A microcomputer program for prediction of individualized optimal drug dosage
based on Bayesian Statistical Theory and Maximum Likelihood Estimation is presented. Model
(one or two compartmental model) and parameter distribution (normal or log normal) can be
selected to describe the plasma drug concentrations-time course. Simplex method is adapted
for contraction of objective function in non-linear least square fitting to the final minimum. It is
designed so that user can integrate universal dosing regimens with different doses, routes, and
regular or irregular intervals. Complex dosage regimens and non steady-state conditions can
be handled. This program can also generate graphic simulations of plasma and peripheral
compartment drug levels of one or two compartmental model. It has been designed to run
interactively to assist learning the pharmacokinetic concept and to be handled by user with
little knowledge on mathematics or computer.
- ISSN
- 0582-6802
- Language
- English
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.