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FLEX-FIT: A Flexible Bayesian Forecasting Program for Dosage Optimization in Clinical Pharmacokinetics
Flex-Fit: Bayesian 원리에 기초한 적정요양 결정을 위한 컴퓨터 프로그램

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Authors
Shin, Sang-Goo; Park, Chan-Woong
Issue Date
1987-12
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.28 No.4, pp. 311-319
Keywords
Computer programBayesian theoremSimplex methodNon-linear least squarePharmacokineticsOne- or two- compartmental modelDosage optimization
Abstract
A microcomputer program for prediction of individualized optimal drug dosage
based on Bayesian Statistical Theory and Maximum Likelihood Estimation is presented. Model
(one or two compartmental model) and parameter distribution (normal or log normal) can be
selected to describe the plasma drug concentrations-time course. Simplex method is adapted
for contraction of objective function in non-linear least square fitting to the final minimum. It is
designed so that user can integrate universal dosing regimens with different doses, routes, and
regular or irregular intervals. Complex dosage regimens and non steady-state conditions can
be handled. This program can also generate graphic simulations of plasma and peripheral
compartment drug levels of one or two compartmental model. It has been designed to run
interactively to assist learning the pharmacokinetic concept and to be handled by user with
little knowledge on mathematics or computer.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6554
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.4 (1987)
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