Oleanolic Acid 유도체의 소염작용에 관한 연구

Abstract

Anti-inflammatory effects of the oleanolic acid derivatives, glycyrrhizine, and hydrocortisone are observed on formalin-induced arthritis in rats. One of the oleanolic acid derivatives, 2-acetoxyll- keto-612 , 13 30-acetoxymethylketo oleanolic acid as well as hydrocortisone has significant action of anti-inflammation upon formalin-induced arthritis in rats, while 2-acetoxy-L11z, 13 28-oxymethylketo oeanolic acid, acetyl oleanolic acid and glycyrrhizine show dou btful results. Serum glutamic oxalacetic transaminase (S-GOT) and serum glutamic pyruvic transaminase (S-GPT) activities increase with 'inflammation, and they are inhibited by anti-inflammatory drugs. Adenosine triphosphatase (ATP-ase) activities in brain and liver tissues do not give any significance to formalin-induced arthritis in rats, but it is increased definitly by anti-inflammatory drugs. There seems to be no relationship between anti-inflammatory effects of anti-inflammatory drugs and activities of S-GOT and S-GPT as well as that of ATP-ase.