S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 18 No.2 (1977)
Imuran이 흰쥐 태자의 흉선발육에 미치는 영향
Effects of Imuran on the Development of Thymus in the Rat Fetuses
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.18 No.2, pp. 63-69
daily doses of azathioprine 5mg and 15mg/kg
body weight on the 4-5th, 8-9th and 12-13th day of
gestation respectively for the study of the effect of
azathioprine on the development of fetal thymus and
lymphatic organs of the rat.
Fetal body weights. external anomalies and fetal death or resorptions were examined. Thymus, spleen
and lymph node were studied histologically in the
Methyl Green-Pyronin, PAS, H-E and Silver stains on
the day of 20th of gestation and on the Ist and 2nd
weeks of neonatal age after their weights were measured.
The results observed under ordinary microscope were
In comparison with control groups, experimental
1. Fetal body weights were decreased slightly, but
the weights of thymus and spleen were decreased
2. In the thymus, the number of immature thyrnocytes
were increased in the cortex, hence the contrast
between cortex and medulla was obscure.
3. In the lymph node, the formation of lymphatic
nodule is delayed, and medium-sized or large lymphocytes
were increased in number diffusely.
4. In the spleen, the number of medium-sized and
large lymphocytes were increased in the inner portion
of periarterial lymphocyte sheath and the size of
white pulp was decreased.
5. In the thymus, spleen and lymph node, mast
cells increased in number and reticular fibers appeared
6. Among the experimental groups, the groups of
drug administration on the 4-5th or 7-8th day of
gestation were affected more severely than the groups
on the l2-13th day of gestation.