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Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses
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- Authors
- Issue Date
- 2003-12-31
- Publisher
- Korean Society of Medical Biochemistry
- Citation
- Experimental and Molecular Medicine 2003;35(6):509-17
- Keywords
- antigens, CD4 ; antigens, differentiation ; cytokines ; T lymphocyte ; T lymphocyte, hyper-inducer ; T lymphocyte subsets
- Abstract
- 4-1BB, a transmembrane molecule, member of the
tumor necrosis factor receptor superfamily, is an
im portant costim ulatory molecule in the immune
response, plays a key role in the clonal expansion
and survival of CD8+ T cells. In this study, we investigated
4-1BB regulation of CD4+ T cell responses
using 4-1BB transgenic (TG) mice that
constitutively expressed 4-1BB on mature T cells.
We first showed that CD4+ T cells of 4-1BB TG
mice had more sustained proliferative capacity in
response to TCR/4-1BB stimulation in vitro compared
to WT mice. Secondly, 4-1BB TG mice
exhibited a more elevated contact hypersensitivity
(CHS) response mediated by CD4+ Th1 cells due
to more vigorous expansion of and apoptotic
inhibition of CD4+ T cells. Finally, CD4+ T cells of
4-1BB TG mice had a heightened capacity for T
cell prim ing. Overall, our results demonstrate the involvement of 4-1BB in CD4+ Th1 cell responses
by regulating the clonal expansion and survival of
CD4+ T cells as seen in CD8+ T cells.
- ISSN
- 1226-3613
- Language
- English
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