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Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells.

Cited 283 time in Web of Science Cited 291 time in Scopus
Authors
Ryoo, Hyun-Mo; Lee, Mi-Hye; Kim, Youn-Jeong
Issue Date
2006-01
Publisher
Elsevier
Citation
Gene 366, 51–57
Keywords
BMP-2TGF-βSmadRunx2OsxDlx5Msx2OsteoblastDifferentiationBone
Abstract
Bone morphogenetic protein (BMP)-2 strongly induces bone formation. Introduction of the protein in muscle tissue results in ectopic bone formation. Similarly, BMP-2 treatment also stimulates the in vitro transdifferentiation of myogenic cells to osteogenic cells. The establishment of an in vitro model system has enabled the investigation of intracellular events including BMP receptor activation, BMP-2-induced R-Smad activation, and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2. Many reviews have addressed events downstream of BMP-receptor binding but few deal with molecular cascades involved in BMP-2-induced osteogenesis. We focus on critical molecular switches, especially transcription factors, and several kinase pathways involved in osteogenic differentiation.
ISSN
0378-1119
Language
English
URI
http://hdl.handle.net/10371/66624
DOI
https://doi.org/10.1016/j.gene.2005.10.011
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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