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Mesenchymal stem cell-mediated functional tooth regeneration in swine

Cited 765 time in Web of Science Cited 828 time in Scopus
Authors
Seo, Byoung-Moo; Sonoyama, Wataru; Liu, Yi; Fang, Dianji; Yamaza, Takayoshi; Zhang, Chunmei; Liu, He; Gronthos, Stan; Wang, Cun-Yu; Shi, Songtao; Wang, Songlin
Issue Date
2006-12
Publisher
Public Library of Science
Citation
Plos One 1(1): e79
Abstract
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance
ISSN
1932-6203
Language
English
URI
https://hdl.handle.net/10371/66628
DOI
https://doi.org/10.1371/journal.pone.0000079
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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