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An Experimental Study on the Cytolytic Effects of Natural Killer cells on Various Types of Lung Carcinoma Cell Lines with Augmented HLA Expressions by Gamma Interferon : 인체 폐종양 세포주에서 MHC 항원 표현 정도와 자연살세포(NK)의 세포 살해 효과와의 상관관계에 관한 연구

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Authors

Lee, Kap No; Park, Seong Hoe; Ham, Eui Keun

Issue Date
1991-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.32 No.2, pp. 57-63
Keywords
Lung carcinoma cell lineMajor histocompatibility complexGamma interferonNK cell
Abstract
Lung carcinoma cell lines (NCI-N417, NCI-NI46, NCI-H69, PC-14) were
evaluated on their expression of HLA-class I with W6/32 antibody and HLA-class II
with L243 by flow cytometry. Also examined were the killing and/or cytolytic effects
of allogeneic NK cells and T lymphocytes as effector cells to the lung carcinoma cell
lines by chromium release assay, before and after treatments with gamma interferon.
HLA class I expressions significantly increased after treatment with gamma interferon
(P <0.05), whereas HLA class II expressions showed no differences (P > 0.05). The
killing and/or cytolytic effects of allogeneic NK cells very significantly decreased after
treatment with gamma interferon (P <0.001), while those of the T lymphocytes showed
either no change or a tendancy to decrease (P > 0.05).
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/6711
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