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Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Ju-Young | - |
dc.contributor.author | Han, Tae Hee | - |
dc.contributor.author | Kim, Jung-Sik | - |
dc.contributor.author | Kim, Sang Woo | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Hwang, Eung-Soo | - |
dc.date.accessioned | 2010-06-28 | - |
dc.date.available | 2010-06-28 | - |
dc.date.issued | 2008-07-25 | - |
dc.identifier.citation | J Clin Virol. 2008t;43(2):223-5 | en |
dc.identifier.issn | 1386-6532 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18650126 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VJV-4T1X2MR-1-1&_cdi=6104&_user=168665&_orig=search&_coverDate=10%2F31%2F2008&_sk=999569997&view=c&wchp=dGLbVtz-zSkzk&md5=c5d4b1912bb9344696982547bdab26ca&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67884 | - |
dc.description.abstract | BACKGROUND: Human bocavirus (hBoV) is regarded as one of the possible etiologic agents in lower respiratory tract infection and bronchial asthma exacerbation in children despite frequent co-detection with other respiratory viruses. The immunologic response in children with hBoV infection is still not clear. OBJECTIVES: To investigate the profiles of T helper-1 (Th1)/T helper-2 (Th2) cytokines in children with hBoV-associated bronchiolitis. STUDY DESIGN: This study utilized of 59 nasopharyngeal aspirates from 59 infants aged 24 months or younger, including 29 from children with hBoV-related bronchiolitis and 30 with respiratory syncytial virus (RSV)-related bronchiolitis. Eighteen infants hospitalized for elective surgeries were included as controls. Nasopharyngeal aspirates were tested simultaneously for cytokines interleukin (IL)-2, IL-4, IL-5, IL-10, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha using the Cytometric Bead Array. RESULTS: Significantly higher concentrations of IFN-gamma (p=0.0001), IL-2 (0.006), and IL-4 (p=0.0002) were observed in hBoV positive specimens than in controls. The concentration of IL-10 (p=0.04) and TNF-alpha (p=0.006) in the RSV-positive group was significantly higher than in the hBoV-positive group, while there was no difference in other cytokines concentration between the two groups. CONCLUSIONS: These results showed that both of Th1 and Th2 cytokines were increased in children with hBoV-related bronchiolitis compared to normal controls, but Th2-polarized responses were not observed. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Acute Disease | en |
dc.subject | Bocavirus/genetics/*immunology/isolation & purification | en |
dc.subject | Bronchiolitis, Viral/*immunology/virology | en |
dc.subject | Child, Preschool | en |
dc.subject | Cytokines/*metabolism | en |
dc.subject | Female | en |
dc.subject | Hospitalization | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Male | en |
dc.subject | Nasopharynx/virology | en |
dc.subject | Parvoviridae Infections/*immunology/virology | en |
dc.subject | Th1 Cells/*immunology | en |
dc.subject | Th2 Cells/*immunology | en |
dc.title | Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정주영 | - |
dc.contributor.AlternativeAuthor | 한태희 | - |
dc.contributor.AlternativeAuthor | 김정식 | - |
dc.contributor.AlternativeAuthor | 김상우 | - |
dc.contributor.AlternativeAuthor | 박정규 | - |
dc.contributor.AlternativeAuthor | 황응수 | - |
dc.identifier.doi | 10.1016/j.jcv.2008.06.008 | - |
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