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Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Kyoung-Ah | - |
dc.contributor.author | Zhang, Rui | - |
dc.contributor.author | Lee, Kyoung Hwa | - |
dc.contributor.author | Chae, Sungwook | - |
dc.contributor.author | Kim, Bum Joon | - |
dc.contributor.author | Kwak, Young Sook | - |
dc.contributor.author | Park, Jae Woo | - |
dc.contributor.author | Lee, Nam Ho | - |
dc.contributor.author | Hyun, Jin Won | - |
dc.date.accessioned | 2010-06-28T03:39:27Z | - |
dc.date.available | 2010-06-28T03:39:27Z | - |
dc.date.issued | 2006-03-31 | - |
dc.identifier.citation | J Radiat Res (Tokyo). 47(1): 61-68 | en |
dc.identifier.issn | 0449-3060 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16571919 | - |
dc.identifier.uri | https://hdl.handle.net/10371/67901 | - |
dc.description.abstract | We studied the cytoprotective effect of triphlorethol-A against gamma-ray radiation-induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by gamma-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS. | en |
dc.language.iso | en | en |
dc.publisher | Japan Radiation Reseach Society | en |
dc.subject | Algae, Brown/*metabolism | en |
dc.subject | Animals | en |
dc.subject | Cell Survival/*drug effects/*radiation effects | en |
dc.subject | Cricetinae | en |
dc.subject | Cricetulus | en |
dc.subject | DNA Damage/*radiation effects | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Fibroblasts/cytology/drug effects/*physiology/radiation effects | en |
dc.subject | Gamma Rays | en |
dc.subject | Lipid Peroxidation/drug effects | en |
dc.subject | Phloroglucinol/administration & dosage/*analogs & derivatives | en |
dc.subject | Radiation-Protective Agents/administration & dosage | en |
dc.subject | Reactive Oxygen Species/*metabolism | en |
dc.title | Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강경아 | - |
dc.contributor.AlternativeAuthor | 이경화 | - |
dc.contributor.AlternativeAuthor | 채성욱 | - |
dc.contributor.AlternativeAuthor | 김범준 | - |
dc.contributor.AlternativeAuthor | 곽영숙 | - |
dc.contributor.AlternativeAuthor | 박재우 | - |
dc.contributor.AlternativeAuthor | 이남호 | - |
dc.contributor.AlternativeAuthor | 현진원 | - |
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