Browse

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Cited 73 time in Web of Science Cited 87 time in Scopus
Authors
Chae, Soo Jin; Kim, Jin Ju; Choi, Young Min; Hwang, Kyu Ri; Jee, Byung Chul; Ku, Seung Yup; Suh, Chang Suk; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong
Issue Date
2008-06-27
Publisher
Oxford University Press
Citation
Hum Reprod. 2008;23(8):1924-1931
Keywords
AdultBlood PressureBody Mass IndexFemaleFollicle Stimulating Hormone/bloodHumansHyperandrogenism/etiologyInsulin/bloodInsulin ResistanceKorea/epidemiologyLuteinizing Hormone/bloodMenstruation Disturbances/etiologyMetabolic Syndrome X/epidemiologyPolycystic Ovary Syndrome/complications/*epidemiology/*physiopathologyPrevalenceRetrospective StudiesTriglycerides/blood
Abstract
BACKGROUND: We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to the subtype of polycystic ovary syndrome (PCOS) in Korean women. METHODS: We recruited 166 women with PCOS and retrospectively recruited 277 controls. PCOS was diagnosed by irregular menstruation (IM), polycystic ovary (PCO) and hyperandrogenism (HA). Subjects were divided into four subgroups: the IM/HA/PCO group (n = 87, 52.4%), the IM/PCO group (n = 52, 31.3%), the IM/HA group (n = 23, 13.9%) and the HA/PCO group (n = 4, 2.4%). Clinical and biochemical variables were compared among the PCOS subgroups. RESULTS: The IM/HA/PCO and IM/HA groups showed higher body mass index (P < 0.001) and waist-to-hip ratio (P < 0.001) than the IM/PCO group. The IM/HA group had higher triglyceride levels than the other groups (P < 0.001). Higher fasting insulin (P < 0.001) and postprandial 2 h insulin (P < 0.01) were noted in the IM/HA/PCO group and the IM/HA group, compared with the IM/PCO group. Women with PCOS showed lower sex hormone-binding globulin (P < 0.001) and higher systolic blood pressure (BP) (P = 0.004), diastolic BP (P = 0.001), fasting insulin (P < 0.001), postprandial 2 h insulin (P < 0.001), homeostatic model for insulin resistance (P < 0.001) and clinical and biochemical parameters of metabolic syndrome (P < 0.05) compared with subjects without PCOS. CONCLUSIONS: Women with PCOS without HA are common in Korea and are less likely to have metabolic dysfunction, insulin resistance and elevated BP. PCOS without HA may be a mild phenotype of PCOS. Therefore, women with PCOS in Korea could have a reduced likelihood of having metabolic syndrome compared with women of other ethnicities.
ISSN
1460-2350 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18579512

http://humrep.oxfordjournals.org/cgi/reprint/23/8/1924.pdf

http://hdl.handle.net/10371/68021
DOI
https://doi.org/10.1093/humrep/den239
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse