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Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women
Cited 79 time in
Web of Science
Cited 95 time in Scopus
- Authors
- Issue Date
- 2008-06-27
- Publisher
- Oxford University Press
- Citation
- Hum Reprod. 2008;23(8):1924-1931
- Keywords
- Adult ; Blood Pressure ; Body Mass Index ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Hyperandrogenism/etiology ; Insulin/blood ; Insulin Resistance ; Korea/epidemiology ; Luteinizing Hormone/blood ; Menstruation Disturbances/etiology ; Metabolic Syndrome X/epidemiology ; Polycystic Ovary Syndrome/complications/*epidemiology/*physiopathology ; Prevalence ; Retrospective Studies ; Triglycerides/blood
- Abstract
- BACKGROUND: We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to the subtype of polycystic ovary syndrome (PCOS) in Korean women. METHODS: We recruited 166 women with PCOS and retrospectively recruited 277 controls. PCOS was diagnosed by irregular menstruation (IM), polycystic ovary (PCO) and hyperandrogenism (HA). Subjects were divided into four subgroups: the IM/HA/PCO group (n = 87, 52.4%), the IM/PCO group (n = 52, 31.3%), the IM/HA group (n = 23, 13.9%) and the HA/PCO group (n = 4, 2.4%). Clinical and biochemical variables were compared among the PCOS subgroups. RESULTS: The IM/HA/PCO and IM/HA groups showed higher body mass index (P < 0.001) and waist-to-hip ratio (P < 0.001) than the IM/PCO group. The IM/HA group had higher triglyceride levels than the other groups (P < 0.001). Higher fasting insulin (P < 0.001) and postprandial 2 h insulin (P < 0.01) were noted in the IM/HA/PCO group and the IM/HA group, compared with the IM/PCO group. Women with PCOS showed lower sex hormone-binding globulin (P < 0.001) and higher systolic blood pressure (BP) (P = 0.004), diastolic BP (P = 0.001), fasting insulin (P < 0.001), postprandial 2 h insulin (P < 0.001), homeostatic model for insulin resistance (P < 0.001) and clinical and biochemical parameters of metabolic syndrome (P < 0.05) compared with subjects without PCOS. CONCLUSIONS: Women with PCOS without HA are common in Korea and are less likely to have metabolic dysfunction, insulin resistance and elevated BP. PCOS without HA may be a mild phenotype of PCOS. Therefore, women with PCOS in Korea could have a reduced likelihood of having metabolic syndrome compared with women of other ethnicities.
- ISSN
- 1460-2350 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18579512
http://humrep.oxfordjournals.org/cgi/reprint/23/8/1924.pdf
https://hdl.handle.net/10371/68021
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