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MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type

Cited 88 time in Web of Science Cited 104 time in Scopus
Authors
Yoon, S O; Jeon, Y K; Paik, J H; Kim, W Y; Kim, Y A; Kim, J E; Kim, C W
Issue Date
2008-08-30
Publisher
Wiley-Blackwell
Citation
Histopathology. 2008; 53(2): 205-217
Keywords
AdultAgedAged, 80 and overB-Lymphocytes/pathologyFemale*Gene DosageGerminal Center/*pathologyHumansIn Situ Hybridization, FluorescenceLymphoma, Large B-Cell, Diffuse/*diagnosis/*genetics/mortality/pathologyMaleMiddle AgedPredictive Value of TestsPrognosisProto-Oncogene Proteins c-bcl-2/geneticsProto-Oncogene Proteins c-bcl-6/geneticsProto-Oncogene Proteins c-myc/*genetics*Translocation, Genetic
Abstract
AIMS: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes in adult DLBCLs to evaluate their clinicopathological features and prognostic implications. METHODS AND RESULTS: Gene status was examined using fluorescence in situ hybridization (FISH), and the results were analysed in the context of germinal centre B-cell (GCB) and non-GCB type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC translocation was more common in GCB type (22%) than in non-GCB type (4.9%), and associated with advanced International Prognostic Index (IPI). MYC aberration, i.e. translocation or increased copy number (ICN), was significantly associated with shorter overall survival, especially for the GCB type. Bcl-2 translocation was rare (3.4%, five of 145), and ICN was observed in 11.7% (17 of 145), more frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended to have an adverse effect on survival. In multivariate analysis, MYC ICN was an independent poor prognostic factor. CONCLUSIONS: Analyses of MYC and Bcl-2 status, i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and determine therapeutic strategies.
ISSN
1365-2559 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18752503

http://hdl.handle.net/10371/68026
DOI
https://doi.org/10.1111/j.1365-2559.2008.03076.x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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