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Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome

Cited 36 time in Web of Science Cited 38 time in Scopus
Authors
Kim, Jin Ju; Choung, Seon Ha; Choi, Young Min; Yoon, Sang Ho; Kim, Seok Hyun; Moon, Shin Yong
Issue Date
2008-01-15
Publisher
Elsevier
Citation
Fertil Steril. 2008;90(6):2318-2323
Keywords
AdultCase-Control StudiesFemaleGenotypeHumansPhenotypePolycystic Ovary Syndrome/*genetics/metabolism*Polymorphism, GeneticReceptors, Androgen/*genetics/metabolismTestosterone/blood*Trinucleotide RepeatsYoung Adult
Abstract
OBJECTIVE: To evaluate the role of the androgen receptor (AR) gene CAG repeat in women with polycystic ovary syndrome (PCOS). DESIGN: Case control study. SETTING: University department of obstetrics and gynecology. PATIENT(S): Women with (n = 114) or without (n = 205) PCOS. INTERVENTION(S): Peripheral blood sampling was done for DNA analysis and serum hormone measurements. MAIN OUTCOME MEASURE(S): CAG repeat length and serum androgen levels. RESULT(S): No statistically significant CAG repeat length differences were found between patients and controls. We conducted a detailed analysis after dividing PCOS patients according to their free testosterone levels. The high free testosterone group had a statistically significantly longer mean biallelic average (24.0 +/- 2.0 vs. 23.0 +/- 1.5), short (22.5 +/- 1.8 vs. 21.7 +/- 1.9), and long (25.5 +/- 2.9 vs. 24.4 +/- 1.9) allelic lengths than the normal free testosterone group. In PCOS patients, a statistically significant correlation was found between biallelic average length and free testosterone concentration, either unadjusted or after adjustment. CONCLUSION(S): The AR gene CAG repeat polymorphism may contribute to the serum concentration of free testosterone in PCOS patients. A subset of PCOS patients with relatively longer CAG repeats (less AR activity) tended to show a higher serum androgen concentration.
ISSN
1556-5653 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18191848

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6K-4RKDHV6-D-1&_cdi=5033&_user=168665&_orig=search&_coverDate=12%2F31%2F2008&_sk=999099993&view=c&wchp=dGLbVzW-zSkWz&md5=c4d62c64f6d713d5fc579fabdbd7bb5e&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68051
DOI
https://doi.org/10.1016/j.fertnstert.2007.10.030
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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