Publications
Detailed Information
Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress
Cited 19 time in
Web of Science
Cited 21 time in Scopus
- Authors
- Issue Date
- 2009-02-03
- Publisher
- Elsevier
- Citation
- FEBS Lett. 583(4), 648-654
- Keywords
- Adenoviridae/genetics ; Anti-Bacterial Agents/pharmacology ; Apoptosis ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Death ; Cell Line ; Culture Media, Serum-Free ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; GTP-Binding Proteins/*metabolism ; Hela Cells ; Humans ; Kidney/cytology ; Leupeptins/pharmacology ; Time Factors ; Transglutaminases/*metabolism ; Ubiquitination ; Oxidative Stress
- Abstract
- Transglutaminase 2 (TG2) is a calcium-dependent enzyme that catalyzes the transamidation reaction. There is conflicting evidence on the role of TG2 in apoptosis. In this report, we show that TG2 increases in response to low level of oxidative stress, whereas TG2 diminishes under high stress conditions. Monitoring TG2 expression, activity and calcium concentration in cells treated with A23187 revealed that the initial rise of calcium activates TG2 but subsequent calcium-overload induces the degradation of TG2 via calcium-mediated polyubiquitination. These results indicate that the role of TG2 in apoptosis depends on the level of calcium influx triggered by oxidative stress.
- ISSN
- 1873-3468 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19183553
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T36-4VGDKWR-2-F&_cdi=4938&_user=168665&_orig=search&_coverDate=02%2F18%2F2009&_sk=994169995&view=c&wchp=dGLzVtz-zSkWA&md5=6fff65f9511699162a762b3c2fa20ce3&ie=/sdarticle.pdf
https://hdl.handle.net/10371/68135
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.