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Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model
Cited 4 time in
Web of Science
Cited 4 time in Scopus
- Authors
- Issue Date
- 2008-08-19
- Citation
- Invest Ophthalmol Vis Sci. 2008;49(12):5340-5345
- Keywords
- Animals ; Delayed-Action Preparations ; Lactic Acid ; Oculomotor Muscles/*drug effects/surgery ; Paclitaxel/*administration & dosage ; Polyglycolic Acid ; Polytetrafluoroethylene ; Postoperative Complications/prevention & control ; Prospective Studies ; Rabbits ; Strabismus/*surgery ; Tissue Adhesions/prevention & control ; Tubulin Modulators/*administration & dosage ; Vision, Binocular ; Drug Delivery Systems ; Suture Techniques
- Abstract
- PURPOSE: To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery. CONCLUSIONS: Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.
- ISSN
- 1552-5783 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18708626
http://www.iovs.org/cgi/reprint/49/12/5340.pdf
https://hdl.handle.net/10371/68197
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