Browse

Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Choung, Ho-Kyung; Jin, Su-Eon; Lee, Min Joung; Kim, Chong-Kook; Hwang, Jeong-Min
Issue Date
2008-08-19
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Invest Ophthalmol Vis Sci. 2008;49(12):5340-5345
Keywords
AnimalsDelayed-Action Preparations*Drug Delivery SystemsLactic AcidOculomotor Muscles/*drug effects/surgeryPaclitaxel/*administration & dosagePolyglycolic AcidPolytetrafluoroethylenePostoperative Complications/prevention & controlProspective StudiesRabbitsStrabismus/*surgery*Suture TechniquesTissue Adhesions/prevention & controlTubulin Modulators/*administration & dosageVision, Binocular
Abstract
PURPOSE: To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery. CONCLUSIONS: Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.
ISSN
1552-5783 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18708626

http://www.iovs.org/cgi/reprint/49/12/5340.pdf

https://hdl.handle.net/10371/68197
DOI
https://doi.org/10.1167/iovs.08-1694
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse