S-Space College of Medicine/School of Medicine (의과대학/대학원) Ophthalmology (안과학전공) Journal Papers (저널논문_안과학전공)
Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model
- Choung, Ho-Kyung; Jin, Su-Eon; Lee, Min Joung; Kim, Chong-Kook; Hwang, Jeong-Min
- Issue Date
- Invest Ophthalmol Vis Sci. 2008;49(12):5340-5345
- Animals; Delayed-Action Preparations; *Drug Delivery Systems; Lactic Acid; Oculomotor Muscles/*drug effects/surgery; Paclitaxel/*administration & dosage; Polyglycolic Acid; Polytetrafluoroethylene; Postoperative Complications/prevention & control; Prospective Studies; Rabbits; Strabismus/*surgery; *Suture Techniques; Tissue Adhesions/prevention & control; Tubulin Modulators/*administration & dosage; Vision, Binocular
- PURPOSE: To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery. CONCLUSIONS: Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.
- 1552-5783 (Electronic)
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