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Anti-cyclic citrullinated peptide antibody is associated with radiographic erosion in rheumatoid arthritis independently of shared epitope status

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Im, Churl Hyun; Kang, Eun Ha; Ryu, Hee Jung; Lee, Jung Hwa; Lee, Eun Young; Lee, Yun Jong; Lee, Eun Bong; Song, Yeong Wook
Issue Date
2008-08-30
Publisher
Springer Verlag
Citation
Rheumatol Int. 29(3):251-256
Keywords
Arthritis, Rheumatoid/blood/*immunology/radiographyAutoantibodies/*bloodEpitopes/*immunologyFemaleHumansKoreaMaleMiddle AgedOdds RatioPeptides, Cyclic/blood/*immunologyRetrospective StudiesRheumatoid Factor/blood
Abstract
Shared epitope (SE) and anti-cyclic citrullinated peptide (CCP) antibody are known to be associated with rheumatoid arthritis (RA). The authors investigated their adjusted effects on RA from Korean population. Clinical features were evaluated in 226 RA patients; 164 healthy controls were enrolled. HLA-DRB1 typing for SE was done by polymerase chain reaction. Anti-CCP antibody levels were determined by enzyme linked immunosorbent assay. Logistic regression analysis method was used for adjusted effects. SE and anti-CCP antibody were associated with RA susceptibility. Anti-CCP antibody was associated with RA susceptibility independent of SE [odds ratio, OR 179.9 (95% confidence interval, CI 40.8-792.2), P < 0.001]. Anti-CCP antibody was associated with radiographic erosive changes independent of SE or rheumatoid factor [OR 3.9 (95% CI 1.1-13.3), P = 0.032]. Anti-CCP antibody was strongly associated with RA susceptibility and radiographic erosion of RA patients, independent of SE in Korean.
ISSN
0172-8172 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18751982

http://www.springerlink.com/content/yp0837j1n67t1004/fulltext.pdf

https://hdl.handle.net/10371/68204
DOI
https://doi.org/10.1007/s00296-008-0690-9
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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