S-Space College of Medicine/School of Medicine (의과대학/대학원) Ophthalmology (안과학전공) Journal Papers (저널논문_안과학전공)
N-myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma
- Issue Date
- Hum Pathol. 2008;39(8):1172-1175
- Adolescent ; Adult ; Child ; Eye Neoplasms/*genetics ; Female ; Genes, myc/*genetics ; Genetic Markers ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Retinoblastoma/*genetics ; Gene Amplification
- In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26 patients who were diagnosed as having unilateral retinoblastoma (highly progressive large retinoblastoma, group 5 in Reese-Ellsworth classification) and underwent enucleation. We performed locus-specific fluorescence in situ hybridization probes for N-myc gene. Our results demonstrated that in only one of 26 patients was N-myc amplification found in retinoblastoma tissue. N-myc amplification has been regarded as one characteristic of retinoblastoma cell line and an adverse prognostic factor. However, our study indicates that N-myc amplification is not frequently found in retinoblastoma.
- 1532-8392 (Electronic)
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