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N-myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Kim, Jeong Hun; Choi, Jin Mi; Yu, Young Suk; Kim, Dong Hun; Kim, Jin Hyoung; Kim, Kyu-Won
Issue Date
2008-06-10
Publisher
Elsevier
Citation
Hum Pathol. 2008;39(8):1172-1175
Keywords
AdolescentAdultChildEye Neoplasms/*geneticsFemale*Gene AmplificationGenes, myc/*geneticsGenetic MarkersHumansIn Situ Hybridization, FluorescenceMaleRetinoblastoma/*genetics
Abstract
In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26 patients who were diagnosed as having unilateral retinoblastoma (highly progressive large retinoblastoma, group 5 in Reese-Ellsworth classification) and underwent enucleation. We performed locus-specific fluorescence in situ hybridization probes for N-myc gene. Our results demonstrated that in only one of 26 patients was N-myc amplification found in retinoblastoma tissue. N-myc amplification has been regarded as one characteristic of retinoblastoma cell line and an adverse prognostic factor. However, our study indicates that N-myc amplification is not frequently found in retinoblastoma.
ISSN
1532-8392 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18538370

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WGD-4SNXT39-1-3&_cdi=6820&_user=168665&_orig=search&_coverDate=08%2F31%2F2008&_sk=999609991&view=c&wchp=dGLbVtz-zSkWA&md5=0a8a6132ca648aa53b24e17dfce7798b&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68205
DOI
https://doi.org/10.1016/j.humpath.2007.12.008
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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